An efficient and metal-free synthesis of 5,7-dimethylcyclopentenon[2,3-c]coumarin was written by Yerramreddy, Thirupathi Reddy;Yiannikouris, Alexandros. And the article was included in Journal of Chemical Research in 2021.Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
A synthesis of 5,7-dimethylcyclopentenon[2,3-c]coumarin I from 3,5-dimethoxyphenol via a Pechmann condensation involved five steps and represented an alternative com. viable approach over existing synthetic protocols in the literature. Operational simplicity, inexpensive key raw materials, short reaction times, and excellent yields were remarkable features of this approach. The aflatoxin template was provided in 55%-67% overall yield from 3,5-dimethoxyphenol with >99% purity, evaluated by high-performance liquid chromatog., 1H NMR, 13C NMR, high-resolution mass spectrometry, and liquid chromatog.-mass spectrometry. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics