Month: November 2022

On May 6, 2016, Vincent, Adrien; Deschamps, Damien; Martzel, Thomas; Lohier, Jean-Francois; Richards, Christopher J.; Gaumont, Annie-Claude; Perrio, Stephane published an article.SDS of cas: 14602-86-9 The title of the article was Enantiomerically Pure [2.2]Paracyclophane-4-thiol: A Planar Chiral Sulfur-Based Building Block Readily Available by Resolution with an Amino Acid Chiral Auxiliary. And the article contained the following:

Acyl chloride of N-phthaloyl-(S)-isoleucine is an efficient chiral auxiliary for the resolution of (±)-[2.2]paracyclophane-4-thiol. A preparative protocol, based on the conversion into diastereoisomeric thiolesters and separation by two fractional crystallizations and column chromatog., was developed. Deprotection with LiAlH4 allowed isolation of the individual thiol enantiomers in good yield (∼40%) and high enantiomeric purity (ee >93%). The absolute configurations were determined by comparison of the optical rotation value of the products with literature data and were confirmed by X-ray crystallog. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).SDS of cas: 14602-86-9

The Article related to chiral paracyclophane thiol preparation resolution amino acid auxiliary, acyl chloride phthaloyl isoleucine auxiliary preparation paracyclophane resolution, crystal mol structure paracyclophane thiol, phthaloyl leucine auxiliary preparation crystal mol structure and other aspects.SDS of cas: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 5, 2020, Shabani, Sadegh; Hutton, Craig A. published an article.Recommanded Product: tert-Butyl trichloroacetimidate The title of the article was Total synthesis of Seongsanamide B. And the article contained the following:

The first total synthesis of the bicyclic depsipeptide natural product seongsanamide B is described. The successful approach employed solid-phase peptide synthesis of a core heptapeptide, incorporating on-resin esterification, followed by solution-phase macrolactamization and a late stage intramol. Evans-Chan-Lam coupling to generate the biaryl ether of the isodityrosine unit. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: tert-Butyl trichloroacetimidate

The Article related to bicyclic depsipeptide natural product seongsanamide b total synthesis, seongsanamide natural product antiallergic agent drug, solid phase synthesis peptide coupling heptapeptide esterification macrolactamization, evans chan lam coupling isodityrosine biaryl ether and other aspects.Recommanded Product: tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cui, Ji-Bin; Wei, Xiao-Xiong; Zhao, Rui; Zhu, Huixia; Shi, Jing; Bierer, Donald; Li, Yi-Ming published an article in 2021, the title of the article was Chemical synthesis of disulfide surrogate peptides by using beta-carbon dimethyl modified diaminodiacids.Name: tert-Butyl trichloroacetimidate And the article contains the following content:

The replacement of disulfide bridges with metabolically stable isosteres is a promising strategy to improve the stability of disulfide-rich polypeptides towards reducing agents and isomerases. A diaminodiacid-based strategy is one of the most effective methods to construct disulfide bond mimics, but modified diaminodiacids have not been developed till now. Inspired by the fact that alkylation of disulfide bonds can regulate the activity of polypeptides, herein, we report the first example of thioether bridged diaminodiacids incorporating Cys Cβ di-Me modification, obtained by penicillamine (Pen)-based thiol alkylation. The utility of these new diaminodiacids was demonstrated by the synthesis of disulfide surrogates of oxytocin containing a short-span disulfide bond and of KIIIA with large-span disulfide bonds. This new type of synthetic bridge further extends the diaminodiacid toolbox to facilitate the study of the structure-activity relationship of disulfide-rich peptides. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Name: tert-Butyl trichloroacetimidate

The Article related to peptide disulfide surrogate synthesis betacarbon dimethyl diaminodiacid, penicillamine thiol disulfide bond alkylation steric hindrance, oxytocin disulfide surrogates synthesis conotoxin kiiia analog, solid phase peptide synthesis oxidative cyclization ncl folding and other aspects.Name: tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 3, 2016, Castanheiro, Thomas; Suffert, Jean; Gulea, Mihaela; Donnard, Morgan published an article.Application of 14602-86-9 The title of the article was Aerobic Copper-Mediated Domino Three-Component Approach to 2-Aminobenzothiazole Derivatives. And the article contained the following:

N-(2-Benzothiazolyl)amides were prepared by the three-component reactions of 2,2′-diaminodiaryl disulfides (or the hydrochloride of an aminotrifluoromethylbenzenethiol), copper cyanide, and acyl, dimethylthiocarbamoyl, or L-menthyloxyformyl chlorides, Boc anhydride, and Ph isocyanate using an oxidative copper-mediated S-cyanation as a key step followed by cyclization and acylation. The reaction proceeds by a mechanism involving an intermol. migration of the acyl group, as scrambling of acyl groups in reactions of acylaminophenyl disulfides was found. The structure of N-(2-benzothiazolyl)-2,5-difluorobenzamide was determined by X-ray crystallog. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application of 14602-86-9

The Article related to benzothiazolyl amide chemoselective preparation, copper cyanide aminoaryl disulfide thiol acyl chloride chemoselective reaction, oxidative cyanation cyclization acylation reaction copper cyanide aminoaryl disulfide, fluorobenzamide benzothiazolyl mol crystal structure and other aspects.Application of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Seno, Manabu; Tsuchiya, Shinji published an article in 1977, the title of the article was Preparation, properties, and x-ray photoelectron spectra of palladium(II) and platinum(II) complexes of amine imides aminimides and sulfur ylides.Synthetic Route of 5034-06-0 And the article contains the following content:

Amine imides RMe2N+N-COR1 (R = PhCH2, p-O2NC6H4CH2; R1 = Me, Et, Ph) and the S ylides Me2S+(O)C-HCOPh with Pd(II) and Pt(II) halides gave ylide-metal complexes PdCl2L2 (L = amine imide), PtCl2[Me2S+(O)C-HCOPh]SEt2, and MCl2[Me2S+(O)C-HCOPh]2 (M = Pd, Pt). IR, 1H and 13C NMR, and x-ray photoelectron spectra indicated that the coordination of the ylide to the metal was through the nucleophilic N+ or C- atom as simple terminal ligands. Cis-PtCl2[Me2S+(O)C-HCOPh]SEt2 released SEt2 in Me2SO giving PtCl2[Me2S+(O)C-HCOPh] which was chelated through the carbanion C and the sulfonium O of the ylide. The thermal properties of the complexes were examined by thermal gravimetric anal. and the nature of the bonding was discussed. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Synthetic Route of 5034-06-0

The Article related to amine imide metal complex, sulfur ylide metal complex, palladium amine imide ylide complex, platinum sulfur ylide complex, ir metal ylide complex, nmr metal ylide complex, photoelectron spectra metal ylide, elec conductivity metal ylide, coordination metal ylide complex and other aspects.Synthetic Route of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 15, 2020, Liu, Jian; Zhou, Jingxian; He, Fengjun; Gao, Liang; Wen, Yu; Gao, Lina; Wang, Ping; Kang, Di; Hu, Lihong published an article.Application of 35444-44-1 The title of the article was Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening. And the article contained the following:

Based on fragment-based virtual screening and bioisosterism strategies, novel indazoles I [R = C6H5, 4-C5H4N, 3-C4H3S etc.; X = C; Y = (CH2)3, (CH2)4, (CH2)6, etc.] and pyrazolo[3,4-b] pyridine derivatives I [R = 3-MeO-C6H4, 4-MeO-C6H4; X = N; Y = (CH2)6] as HDACs inhibitors were synthesized and evaluated. Most of these compounds displayed good to excellent inhibitory activities against HDACs, especially compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] were identified as potent inhibitors of HDAC1 (IC50 = 2.7 nM and IC50 = 3.1 nM), HDAC2 (IC50 = 4.2 nM and IC50 = 3.6 nM) and HDAC8 (IC50 = 3.6 nM and IC50 = 3.3 nM). Further anti-proliferation assays revealed that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] showed better anti-proliferative activities against HCT-116 and HeLa cells than pos. control SAHA. The western blot anal. results indicated that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] noticeably up-regulated the level of acetylated α-tubulin and histone H3. In addition, the two compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] could arrest cell cycle in G2/M phase and promote cell apoptosis, which was similar as the reference compound SAHA. Through the mol. docking and dynamic studies, the potent HDAC inhibitory activities mainly caused by van der Waals and electrostatic interactions with the HDACs. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application of 35444-44-1

The Article related to arylindazolyl hydroxy alkanediamide preparation antitumor hdac inhibition sar docking, phenylpyrazolopyridinyl hydroxy alkanediamide preparation antitumor hdac inhibition sar docking, antitumor activity, fragment-based drug design, hdac, hdac inhibitors, indazole scaffold and other aspects.Application of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 23, 2022, Varkhedkar, Rajesh; Yang, Fan; Dontha, Rakesh; Zhang, Jianglin; Liu, Jiyong; Spingler, Bernhard; van der Veen, Stijn; Duttwyler, Simon published an article.HPLC of Formula: 14602-86-9 The title of the article was Natural-Product-Directed Catalytic Stereoselective Synthesis of Functionalized Fused Borane Cluster-Oxazoles for the Discovery of Bactericidal Agents. And the article contained the following:

The identification of an alternative chem. space to address the global challenge posed by emerging antimicrobial resistance is very much needed for the discovery of novel antimicrobial lead compounds B clusters are currently being explored in drug discovery due to their unique steric and electronic properties. However, the challenges associated with the synthesis and derivatization techniques of these compounds have limited their utility in the rapid construction of a library of mols. for screening against various biol. targets as an alternative mol. platform. Herein, the authors report a transition-metal-catalyzed regioselective direct B-H alkylation-annulation of the closo-dodecaborate anion with natural products such as menthol and camphor as the directing groups. This method allowed the rapid construction of a library of 1,2,3-trisubstituted clusters, which were evaluated in terms of their antibacterial activity against WHO priority pathogens. Several of the synthesized dodecaborate derivatives displayed medium- to high-level bactericidal activity against Gram-pos. and Gram-neg. bacteria. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).HPLC of Formula: 14602-86-9

The Article related to mentholdiboraoxazole fused carborane preparation antibacterial activity, crystal structure mentholdiboraoxazole fused carborane, mol structure mentholdiboraoxazole fused carborane, rhodium catalyzed regioselective alkylation annulation dodecaborate anion styrene derivative and other aspects.HPLC of Formula: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 14, 2020, Shepard, Stacey; Combs, Andrew P. published a patent.SDS of cas: 877149-10-5 The title of the patent was Preparation of heterocyclic derivatives as PI3K inhibitors. And the patent contained the following:

This invention relates to compounds I [Z = CZ1 or N; Z1 and R12 = (independently) H, D, OH, NO2, etc.; R1 = H, D, halo, alkyl, etc.; R2 = H, D, halo, alkyl, etc.; R6 = H, D, halo, alkyl, etc.; X9 = (un)substituted NH or CH2; X11 = (un)substituted NH or CH2; R = H, alkyl, alkenyl, etc.] or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases. E.g., a multi-step synthesis of (S)-II, starting from 4-bromopyridine-2-carbonitrile, was disclosed. The exemplified compounds I were tested in the PI3Kγ, PI3Kδ, and PI3Kγ THP1 RPS6 ELISA assays (data given). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of Methyl 4-bromo-2-chloro-6-methylbenzoate(cas: 877149-10-5).SDS of cas: 877149-10-5

The Article related to heterocyclic derivative preparation pi3k gamma inhibitor antitumor cardiovascular, autoimmune neurodegenerative disease treatment heterocyclic derivative preparation pi3k gamma, heteroarylpyridazinyl heteroarylpyridyl isoindolinone indazole preparation pi3k gamma inhibitor and other aspects.SDS of cas: 877149-10-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 3, 2016, Baum, Erich W.; Fischer, Lindsey G.; Crouse, Gary D.; Sparks, Thomas C. published a patent.SDS of cas: 38939-88-7 The title of the patent was Preparation of 5-(1,2,4-triazol-3-yl)indan-2-ylurea and 6-(1,2,4-triazol-3-yl)-1,2,3,4-tetrahydronaphthalen-2-ylurea derivatives as pesticides, and intermediates, compositions, and processes related thereto. And the patent contained the following:

This disclosure relates to the field of mols. having pesticidal utility against pests such as Phylum nematoda, Arthropoda, and/or Mohusca, processes to produce such mols. and intermediates used in such processes, compositions containing such mols., and processes of using such mols. against such pests. More specifically the title compounds I [R1, R2, R3, R4, R5, R6, R7, R9 = independently H, F, Cl, Br, iodo, cyano, NO2, OH, or each (un)substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C3-6cycloalkyl, or C3-6cycloalkoxy; R8 = H; L = (un)substituted C1-4 alkyl; R10 = H or each (un)substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, (C1-4 alkyl)(C3-6 cycloalkyl), C1-4 alkylphenyl, C1-4 alkylheterocyclyl, (C1-4 alkyl)O(C1-4 alkyl), (C1-4 alkyl)OC(O)(C1-4 alkyl), (C1-4 alkyl)OC(O)O(C1-4 alkyl), C(O)(C1-4 alkyl), or C(O)phenyl, wherein each alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl; R11, R12, R13, R14, R15 = each independently H, F, Cl, Br, iodo, cyano, NO2, OH, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C3-6 cycloalkyl, or C3-6 cycloalkoxy; R16, R17 = independently group (G), H, or each (un)substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, (C1-4 alkyl)(C3-6 cycloalkyl), C1-4 alkylphenyl, C1-4 alkylheterocyclyl, (C1-4 alkyl)C(O)(C1-4 alkyl), or (C1-4 alkyl)C(O)O(C1-4 alkyl); group (G) = (un)substituted 4 to 8 membered heterocyclyl ring formed by taking R16 and R17 together with (S)-Cx(Nx)] are prepared The compounds I may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. Thus, dichloromethane (4 mL), water (2 mL), and sodium bicarbonate (0.271 g, 3.22 mmol) were added 5-[1-[4-(trifluoromethoxy)phenyl]-1H-1,2,4-triazol-3-yl]-2,3-dihydro-1H-inden-2-amine dihydrochloride (0.279 g, 0.645 mmol) in a vial (25 mL) equipped with a stir bar under nitrogen. The resulting mixture was cooled in an ice water bath, followed by adding triphosgene (0.0770 g, 0.258 mmol) in one portion and the resulting reaction was stirred vigorously until the conversion of the starting material was observed After workup, the solid obtained was suspended in acetonitrile (6 mL) in a round-bottomed flask (100 mL) equipped with a stir bar under nitrogen, treated with cesium carbonate (0.231 g, 0.709 mmol) and 1-(2-isopropyl-5-methylphenyl)thiourea (0.134 g, 0.645 mmol), and stirred overnight at room temperature to give, after workup and flash chromatog., 39% 1-[(2-isopropyl-5-methylphenyl)carbamothioyl]-3-[5-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]indan-2-yl]urea (II). II controlled 50-100% beet armyworm (Spodoptera exigua) and cabbage looper (Thchoplusia ni) and 80-100% yellow fever mosquito (Aedes aegypti) eggs. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).SDS of cas: 38939-88-7

The Article related to triazolylindanylurea triazolyltetrahydronaphthalenylurea preparation pesticide, nematicide acaricide insecticide triazolylindanylurea triazolyltetrahydronaphthalenylurea preparation, miticides molluscicide triazolylindanylurea triazolyltetrahydronaphthalenylurea preparation and other aspects.SDS of cas: 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 19, 2020, Wang, Ze-Shu; Chen, Yang-Bo; Zhang, Hao-Wen; Sun, Zhou; Zhu, Chunyin; Ye, Long-Wu published an article.Reference of 2-Amino-4-chlorobenzoic acid The title of the article was Ynamide Smiles Rearrangement Triggered by Visible-Light-Mediated Regioselective Ketyl-Ynamide Coupling: Rapid Access to Functionalized Indoles and Isoquinolines. And the article contained the following:

Here, a novel and practical radical Smiles rearrangement triggered by photoredox-catalyzed regioselective ketyl-ynamide coupling is reported, which represents the first radical Smiles rearrangement of ynamides. This method enables facile access to a variety of valuable 2-benzhydrylindoles with broad substrate scope in generally good yields under mild reaction conditions. In addition, this chem. can also be extended to the divergent synthesis of versatile 3-benzhydrylisoquinolines through a similar ketyl-ynamide coupling and radical Smiles rearrangement, followed by dehydrogenative oxidation Moreover, such an ynamide Smiles rearrangement initiated by intermol. photoredox catalysis via addition of external radical sources is also achieved. By control experiments, the reaction was shown to proceed via key ketyl radical and α-imino carbon radical intermediates. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Reference of 2-Amino-4-chlorobenzoic acid

The Article related to cascade regioselective coupling smiles rearrangement iridium photocatalyst, benzoylbenzyl ethynylsulfonamide preparation coupling regioselective smiles rearrangement iridium photocatalyst, indole benzhydryl preparation, isoquinoline benzhydryl preparation and other aspects.Reference of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics