Month: November 2022

On March 1, 2021, Wang, Xiu Li; Zhang, Jing Yuan; Chang, Zhi Han; Zhang, Zhong; Wang, Xiang; Lin, Hong Yan; Cui, Zi Wei published an article.HPLC of Formula: 4569-86-2 The title of the article was α-γ-Type [Mo8O26]4–Containing Metal-Organic Complex Possessing Efficient Catalytic Activity toward the Oxidation of Thioether Derivatives. And the article contained the following:

In this work, a new α-γ-type [Mo8O26]4- anion was first synthesized and characterized by single-crystal X-ray diffraction anal. and was obtained by introducing molybdate to the synthesis of metal-organic complex (MOC) under hydrothermal conditions. An octamolybdate-based MOC, namely, {[Cu8(H2O)6](dpyh)4(α-γ-Mo8O26) }·(β-Mo8O26)·8.5H2O (1) (H2dpyh = N,N-bis(3-pyrazolamide)-1,2-hexahydrobenzene), was obtained. The α-γ-type [Mo8O26]4- anion was composed of four MoO6 octahedra and four MoO5 trigonal bipyramids by sharing their edges and corners. The title complex exhibited a 1D structure in which an α-γ-type [Mo8O26]4- anion was connected with [Cu4(dpyh)2] units in a staggered manner. Under optimized conditions, complex 1 as the catalyst can achieve a highly efficient conversion (more than 99%) of thioanisole within 30 min and above 99% selectivity toward sulfoxide. Furthermore, efficient catalytic oxidation of thioether derivatives was also performed with 1 as the catalyst. In addition, the stable electrochem. sensing performance and adsorption capacity toward organic dyes were tested. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).HPLC of Formula: 4569-86-2

The Article related to crystal structure redox potential organic dye adsorption polyoxometalate preparation, thioether sulfoxide sulfoxidation catalyst polyoxomolybdate copper pyrazolamide complex, electrochem redox catalysis amperometric sensor octamolybdate metal organic complex and other aspects.HPLC of Formula: 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Komar, Mario; Kraljevic, Tatjana Gazivoda; Jerkovic, Igor; Molnar, Maja published an article in 2022, the title of the article was Application of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Selected Green Chemistry Methods.Electric Literature of 89-77-0 And the article contains the following content:

In this study, deep eutectic solvents (DESs) were used as green and eco-friendly media for the synthesis of substituted 2-mercaptoquinazolin-4(3H)-ones I [R1 = H, 6-I, 6-Br, 7-Cl, 6,8-dichloro; R2 = Me, Ph, Bn, etc.] from different anthranilic acids and aliphatic or aromatic isothiocyanates. A model reaction on anthranilic acid and Ph isothiocyanate was performed in 20 choline chloride-based DESs at 80 °C to find the best solvent. Based on the product yield, choline chloride:urea (1:2) DES was found to be the most effective, while DESs acted both as solvents and catalysts. Desired compounds were prepared with moderate to good yields using stirring, microwave-assisted, and ultrasound-assisted synthesis. Significantly higher yields were obtained with mixing and ultrasonication (16-76%), while microwave-induced synthesis showed lower effectiveness (13-49%). The structures of the synthesized compounds were confirmed by 1H and 13C NMR spectroscopy. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Electric Literature of 89-77-0

The Article related to mercaptoquinazolinone green preparation, anthranilic acid isothiocyanate microwave ultrasound choline chloride urea catalyst, 2-mercaptoquinazolin-4(3h)-one, deep eutectic solvents, green chemistry, microwave-assisted synthesis, ultrasound-assisted synthesis and other aspects.Electric Literature of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 4, 2020, He, Tingting; Peng, Lei; Li, Shan; Hu, Fangli; Xie, Chuandong; Huang, Shengli; Jia, Shiqi; Qin, Wenling; Yan, Hailong published an article.Product Details of 98946-18-0 The title of the article was Chiral Naphthyl-C2-Indole as Scaffold for Phosphine Organocatalysis: Application in Asymmetric Formal [4 + 2] Cycloaddition Reactions. And the article contained the following:

The applications of a newly designed chiral naphthyl-C2-indole bifunctional phosphine organocatalyst I in stereoselective formal [4 + 2] cycloaddition reactions were reported. The chiral naphthyl-C2-indole skeleton was introduced to bifunctional phosphine organocatalysis for the first time, and excellent stereocontrol was achieved in formal [4 + 2] cycloaddition reactions of dicyanomethyleneoxindoles II (R1 = Me, MeOCH2, H2C:CHCH2, PhCH2, Ph; R2 = H, 5-Me, 7-Me, 6-MeO, 6-MeO, 7-F3C, 5-Cl, 5-Br, 6-Br) with pentadienones (E)-R3CH:CHCOCH:CH2 (R3 = Ph, 4-MeC6H4, 2-MeOC6H4, 4-MeOC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 2-furyl) and of oxoindolylideneacetates III (R4 = H, Me, MeOCH2, H2C:CHCH2, Boc, Ph, PhCH2, PhCO; R5 = H, 5-Me, 7-Me, 5, 7-Me2, 5-MeO, 6-MeO, 5-F, 5-Cl, 6-Cl, 5-Br, 6-Br, 7-Br; X = CH, N) with 3-acryloylbenzofuran. With the optimal catalyst, chiral spirooxindoles IV (R1 = Me, MeOCH2, H2C:CHCH2, PhCH2, Ph; R2 = H, 5-Me, 7-Me, 6-MeO, 6-MeO, 7-F3C, 5-Cl, 5-Br, 6-Br; R3 = Ph, 4-MeC6H4, 2-MeOC6H4, 4-MeOC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 2-furyl) and spirodibenzofuranoxindoles V (R4 = H, Me, MeOCH2, H2C:CHCH2, Boc, Ph, PhCH2, PhCO; R5 = H, 5-Me, 7-Me, 5, 7-Me2, 5-MeO, 6-MeO, 5-F, 5-Cl, 6-Cl, 5-Br, 6-Br, 7-Br; X = CH, N) were produced in moderate to good yields with excellent stereoselectivities (up to >99% ee, >20:1 dr). The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Product Details of 98946-18-0

The Article related to phosphinoindolylnaphthol nonracemic preparation organocatalyst, spirooxindole spirodibenzofuranoxindole diastereoselective enantioselective preparation, stereoselective formal cycloaddition dicyanomethyleneoxindole pentadienone phosphinoindolylnaphthol catalyst and other aspects.Product Details of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 6, 2016, Vincent, Adrien; Deschamps, Damien; Martzel, Thomas; Lohier, Jean-Francois; Richards, Christopher J.; Gaumont, Annie-Claude; Perrio, Stephane published an article.SDS of cas: 14602-86-9 The title of the article was Enantiomerically Pure [2.2]Paracyclophane-4-thiol: A Planar Chiral Sulfur-Based Building Block Readily Available by Resolution with an Amino Acid Chiral Auxiliary. And the article contained the following:

Acyl chloride of N-phthaloyl-(S)-isoleucine is an efficient chiral auxiliary for the resolution of (±)-[2.2]paracyclophane-4-thiol. A preparative protocol, based on the conversion into diastereoisomeric thiolesters and separation by two fractional crystallizations and column chromatog., was developed. Deprotection with LiAlH4 allowed isolation of the individual thiol enantiomers in good yield (∼40%) and high enantiomeric purity (ee >93%). The absolute configurations were determined by comparison of the optical rotation value of the products with literature data and were confirmed by X-ray crystallog. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).SDS of cas: 14602-86-9

The Article related to chiral paracyclophane thiol preparation resolution amino acid auxiliary, acyl chloride phthaloyl isoleucine auxiliary preparation paracyclophane resolution, crystal mol structure paracyclophane thiol, phthaloyl leucine auxiliary preparation crystal mol structure and other aspects.SDS of cas: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 5, 2020, Shabani, Sadegh; Hutton, Craig A. published an article.Recommanded Product: tert-Butyl trichloroacetimidate The title of the article was Total synthesis of Seongsanamide B. And the article contained the following:

The first total synthesis of the bicyclic depsipeptide natural product seongsanamide B is described. The successful approach employed solid-phase peptide synthesis of a core heptapeptide, incorporating on-resin esterification, followed by solution-phase macrolactamization and a late stage intramol. Evans-Chan-Lam coupling to generate the biaryl ether of the isodityrosine unit. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: tert-Butyl trichloroacetimidate

The Article related to bicyclic depsipeptide natural product seongsanamide b total synthesis, seongsanamide natural product antiallergic agent drug, solid phase synthesis peptide coupling heptapeptide esterification macrolactamization, evans chan lam coupling isodityrosine biaryl ether and other aspects.Recommanded Product: tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cui, Ji-Bin; Wei, Xiao-Xiong; Zhao, Rui; Zhu, Huixia; Shi, Jing; Bierer, Donald; Li, Yi-Ming published an article in 2021, the title of the article was Chemical synthesis of disulfide surrogate peptides by using beta-carbon dimethyl modified diaminodiacids.Name: tert-Butyl trichloroacetimidate And the article contains the following content:

The replacement of disulfide bridges with metabolically stable isosteres is a promising strategy to improve the stability of disulfide-rich polypeptides towards reducing agents and isomerases. A diaminodiacid-based strategy is one of the most effective methods to construct disulfide bond mimics, but modified diaminodiacids have not been developed till now. Inspired by the fact that alkylation of disulfide bonds can regulate the activity of polypeptides, herein, we report the first example of thioether bridged diaminodiacids incorporating Cys Cβ di-Me modification, obtained by penicillamine (Pen)-based thiol alkylation. The utility of these new diaminodiacids was demonstrated by the synthesis of disulfide surrogates of oxytocin containing a short-span disulfide bond and of KIIIA with large-span disulfide bonds. This new type of synthetic bridge further extends the diaminodiacid toolbox to facilitate the study of the structure-activity relationship of disulfide-rich peptides. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Name: tert-Butyl trichloroacetimidate

The Article related to peptide disulfide surrogate synthesis betacarbon dimethyl diaminodiacid, penicillamine thiol disulfide bond alkylation steric hindrance, oxytocin disulfide surrogates synthesis conotoxin kiiia analog, solid phase peptide synthesis oxidative cyclization ncl folding and other aspects.Name: tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 3, 2016, Castanheiro, Thomas; Suffert, Jean; Gulea, Mihaela; Donnard, Morgan published an article.Application of 14602-86-9 The title of the article was Aerobic Copper-Mediated Domino Three-Component Approach to 2-Aminobenzothiazole Derivatives. And the article contained the following:

N-(2-Benzothiazolyl)amides were prepared by the three-component reactions of 2,2′-diaminodiaryl disulfides (or the hydrochloride of an aminotrifluoromethylbenzenethiol), copper cyanide, and acyl, dimethylthiocarbamoyl, or L-menthyloxyformyl chlorides, Boc anhydride, and Ph isocyanate using an oxidative copper-mediated S-cyanation as a key step followed by cyclization and acylation. The reaction proceeds by a mechanism involving an intermol. migration of the acyl group, as scrambling of acyl groups in reactions of acylaminophenyl disulfides was found. The structure of N-(2-benzothiazolyl)-2,5-difluorobenzamide was determined by X-ray crystallog. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application of 14602-86-9

The Article related to benzothiazolyl amide chemoselective preparation, copper cyanide aminoaryl disulfide thiol acyl chloride chemoselective reaction, oxidative cyanation cyclization acylation reaction copper cyanide aminoaryl disulfide, fluorobenzamide benzothiazolyl mol crystal structure and other aspects.Application of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Seno, Manabu; Tsuchiya, Shinji published an article in 1977, the title of the article was Preparation, properties, and x-ray photoelectron spectra of palladium(II) and platinum(II) complexes of amine imides aminimides and sulfur ylides.Synthetic Route of 5034-06-0 And the article contains the following content:

Amine imides RMe2N+N-COR1 (R = PhCH2, p-O2NC6H4CH2; R1 = Me, Et, Ph) and the S ylides Me2S+(O)C-HCOPh with Pd(II) and Pt(II) halides gave ylide-metal complexes PdCl2L2 (L = amine imide), PtCl2[Me2S+(O)C-HCOPh]SEt2, and MCl2[Me2S+(O)C-HCOPh]2 (M = Pd, Pt). IR, 1H and 13C NMR, and x-ray photoelectron spectra indicated that the coordination of the ylide to the metal was through the nucleophilic N+ or C- atom as simple terminal ligands. Cis-PtCl2[Me2S+(O)C-HCOPh]SEt2 released SEt2 in Me2SO giving PtCl2[Me2S+(O)C-HCOPh] which was chelated through the carbanion C and the sulfonium O of the ylide. The thermal properties of the complexes were examined by thermal gravimetric anal. and the nature of the bonding was discussed. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Synthetic Route of 5034-06-0

The Article related to amine imide metal complex, sulfur ylide metal complex, palladium amine imide ylide complex, platinum sulfur ylide complex, ir metal ylide complex, nmr metal ylide complex, photoelectron spectra metal ylide, elec conductivity metal ylide, coordination metal ylide complex and other aspects.Synthetic Route of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 15, 2020, Liu, Jian; Zhou, Jingxian; He, Fengjun; Gao, Liang; Wen, Yu; Gao, Lina; Wang, Ping; Kang, Di; Hu, Lihong published an article.Application of 35444-44-1 The title of the article was Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening. And the article contained the following:

Based on fragment-based virtual screening and bioisosterism strategies, novel indazoles I [R = C6H5, 4-C5H4N, 3-C4H3S etc.; X = C; Y = (CH2)3, (CH2)4, (CH2)6, etc.] and pyrazolo[3,4-b] pyridine derivatives I [R = 3-MeO-C6H4, 4-MeO-C6H4; X = N; Y = (CH2)6] as HDACs inhibitors were synthesized and evaluated. Most of these compounds displayed good to excellent inhibitory activities against HDACs, especially compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] were identified as potent inhibitors of HDAC1 (IC50 = 2.7 nM and IC50 = 3.1 nM), HDAC2 (IC50 = 4.2 nM and IC50 = 3.6 nM) and HDAC8 (IC50 = 3.6 nM and IC50 = 3.3 nM). Further anti-proliferation assays revealed that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] showed better anti-proliferative activities against HCT-116 and HeLa cells than pos. control SAHA. The western blot anal. results indicated that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] noticeably up-regulated the level of acetylated α-tubulin and histone H3. In addition, the two compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] could arrest cell cycle in G2/M phase and promote cell apoptosis, which was similar as the reference compound SAHA. Through the mol. docking and dynamic studies, the potent HDAC inhibitory activities mainly caused by van der Waals and electrostatic interactions with the HDACs. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application of 35444-44-1

The Article related to arylindazolyl hydroxy alkanediamide preparation antitumor hdac inhibition sar docking, phenylpyrazolopyridinyl hydroxy alkanediamide preparation antitumor hdac inhibition sar docking, antitumor activity, fragment-based drug design, hdac, hdac inhibitors, indazole scaffold and other aspects.Application of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 23, 2022, Varkhedkar, Rajesh; Yang, Fan; Dontha, Rakesh; Zhang, Jianglin; Liu, Jiyong; Spingler, Bernhard; van der Veen, Stijn; Duttwyler, Simon published an article.HPLC of Formula: 14602-86-9 The title of the article was Natural-Product-Directed Catalytic Stereoselective Synthesis of Functionalized Fused Borane Cluster-Oxazoles for the Discovery of Bactericidal Agents. And the article contained the following:

The identification of an alternative chem. space to address the global challenge posed by emerging antimicrobial resistance is very much needed for the discovery of novel antimicrobial lead compounds B clusters are currently being explored in drug discovery due to their unique steric and electronic properties. However, the challenges associated with the synthesis and derivatization techniques of these compounds have limited their utility in the rapid construction of a library of mols. for screening against various biol. targets as an alternative mol. platform. Herein, the authors report a transition-metal-catalyzed regioselective direct B-H alkylation-annulation of the closo-dodecaborate anion with natural products such as menthol and camphor as the directing groups. This method allowed the rapid construction of a library of 1,2,3-trisubstituted clusters, which were evaluated in terms of their antibacterial activity against WHO priority pathogens. Several of the synthesized dodecaborate derivatives displayed medium- to high-level bactericidal activity against Gram-pos. and Gram-neg. bacteria. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).HPLC of Formula: 14602-86-9

The Article related to mentholdiboraoxazole fused carborane preparation antibacterial activity, crystal structure mentholdiboraoxazole fused carborane, mol structure mentholdiboraoxazole fused carborane, rhodium catalyzed regioselective alkylation annulation dodecaborate anion styrene derivative and other aspects.HPLC of Formula: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics