Month: November 2022

On May 14, 2020, Shepard, Stacey; Combs, Andrew P. published a patent.SDS of cas: 877149-10-5 The title of the patent was Preparation of heterocyclic derivatives as PI3K inhibitors. And the patent contained the following:

This invention relates to compounds I [Z = CZ1 or N; Z1 and R12 = (independently) H, D, OH, NO2, etc.; R1 = H, D, halo, alkyl, etc.; R2 = H, D, halo, alkyl, etc.; R6 = H, D, halo, alkyl, etc.; X9 = (un)substituted NH or CH2; X11 = (un)substituted NH or CH2; R = H, alkyl, alkenyl, etc.] or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases. E.g., a multi-step synthesis of (S)-II, starting from 4-bromopyridine-2-carbonitrile, was disclosed. The exemplified compounds I were tested in the PI3Kγ, PI3Kδ, and PI3Kγ THP1 RPS6 ELISA assays (data given). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of Methyl 4-bromo-2-chloro-6-methylbenzoate(cas: 877149-10-5).SDS of cas: 877149-10-5

The Article related to heterocyclic derivative preparation pi3k gamma inhibitor antitumor cardiovascular, autoimmune neurodegenerative disease treatment heterocyclic derivative preparation pi3k gamma, heteroarylpyridazinyl heteroarylpyridyl isoindolinone indazole preparation pi3k gamma inhibitor and other aspects.SDS of cas: 877149-10-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 3, 2016, Baum, Erich W.; Fischer, Lindsey G.; Crouse, Gary D.; Sparks, Thomas C. published a patent.SDS of cas: 38939-88-7 The title of the patent was Preparation of 5-(1,2,4-triazol-3-yl)indan-2-ylurea and 6-(1,2,4-triazol-3-yl)-1,2,3,4-tetrahydronaphthalen-2-ylurea derivatives as pesticides, and intermediates, compositions, and processes related thereto. And the patent contained the following:

This disclosure relates to the field of mols. having pesticidal utility against pests such as Phylum nematoda, Arthropoda, and/or Mohusca, processes to produce such mols. and intermediates used in such processes, compositions containing such mols., and processes of using such mols. against such pests. More specifically the title compounds I [R1, R2, R3, R4, R5, R6, R7, R9 = independently H, F, Cl, Br, iodo, cyano, NO2, OH, or each (un)substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C3-6cycloalkyl, or C3-6cycloalkoxy; R8 = H; L = (un)substituted C1-4 alkyl; R10 = H or each (un)substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, (C1-4 alkyl)(C3-6 cycloalkyl), C1-4 alkylphenyl, C1-4 alkylheterocyclyl, (C1-4 alkyl)O(C1-4 alkyl), (C1-4 alkyl)OC(O)(C1-4 alkyl), (C1-4 alkyl)OC(O)O(C1-4 alkyl), C(O)(C1-4 alkyl), or C(O)phenyl, wherein each alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl; R11, R12, R13, R14, R15 = each independently H, F, Cl, Br, iodo, cyano, NO2, OH, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C3-6 cycloalkyl, or C3-6 cycloalkoxy; R16, R17 = independently group (G), H, or each (un)substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, (C1-4 alkyl)(C3-6 cycloalkyl), C1-4 alkylphenyl, C1-4 alkylheterocyclyl, (C1-4 alkyl)C(O)(C1-4 alkyl), or (C1-4 alkyl)C(O)O(C1-4 alkyl); group (G) = (un)substituted 4 to 8 membered heterocyclyl ring formed by taking R16 and R17 together with (S)-Cx(Nx)] are prepared The compounds I may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. Thus, dichloromethane (4 mL), water (2 mL), and sodium bicarbonate (0.271 g, 3.22 mmol) were added 5-[1-[4-(trifluoromethoxy)phenyl]-1H-1,2,4-triazol-3-yl]-2,3-dihydro-1H-inden-2-amine dihydrochloride (0.279 g, 0.645 mmol) in a vial (25 mL) equipped with a stir bar under nitrogen. The resulting mixture was cooled in an ice water bath, followed by adding triphosgene (0.0770 g, 0.258 mmol) in one portion and the resulting reaction was stirred vigorously until the conversion of the starting material was observed After workup, the solid obtained was suspended in acetonitrile (6 mL) in a round-bottomed flask (100 mL) equipped with a stir bar under nitrogen, treated with cesium carbonate (0.231 g, 0.709 mmol) and 1-(2-isopropyl-5-methylphenyl)thiourea (0.134 g, 0.645 mmol), and stirred overnight at room temperature to give, after workup and flash chromatog., 39% 1-[(2-isopropyl-5-methylphenyl)carbamothioyl]-3-[5-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]indan-2-yl]urea (II). II controlled 50-100% beet armyworm (Spodoptera exigua) and cabbage looper (Thchoplusia ni) and 80-100% yellow fever mosquito (Aedes aegypti) eggs. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).SDS of cas: 38939-88-7

The Article related to triazolylindanylurea triazolyltetrahydronaphthalenylurea preparation pesticide, nematicide acaricide insecticide triazolylindanylurea triazolyltetrahydronaphthalenylurea preparation, miticides molluscicide triazolylindanylurea triazolyltetrahydronaphthalenylurea preparation and other aspects.SDS of cas: 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics