Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development [Erratum to document cited in CA163:218209] was written by Shaw, Scott A.;Balasubramanian, Balu;Bonacorsi, Samuel;Caceres Cortes, Janet;Cao, Kevin;Chen, Bang-Chi;Dai, Jun;Decicco, Carl;Goswami, Animesh;Guo, Zhiwei;Hanson, Ronald;Humphreys, W. Griffith;Lam, Patrick Y. S.;Li, Wenying;Mathur, Arvind;Maxwell, Brad D.;Michaudel, Quentin;Peng, Li;Pudzianowski, Andrew;Qiu, Feng;Su, Shun;Sun, Dawn;Tymiak, Adrienne A.;Vokits, Benjamin P.;Wang, Bei;Wexler, Ruth;Wu, Dauh-Rurng;Zhang, Yingru;Zhao, Rulin;Baran, Phil S.. And the article was included in Journal of Organic Chemistry in 2015.Safety of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate The following contents are mentioned in the article:
Other work on clopidogrel metabolite synthesis was omitted from the reference list; a corrected reference 13 is given. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Safety of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate).
(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics