Beattie, Karren D. published the artcileAntibacterial and antifungal screening of natural products sourced from Australian fungi and characterization of pestalactams D-F, Product Details of C8H7ClO3, the publication is Phytochemistry (Elsevier) (2016), 79-85, database is CAplus and MEDLINE.
Eighteen natural products sourced from Australian micro- or macro-fungi were screened for antibacterial and antifungal activity. This focused library was comprised of caprolactams, polyamines, quinones, and polyketides, with addnl. large-scale isolation studies undertaken in order to resupply previously identified compounds Chem. investigations of the re-fermented culture from the endophytic fungus Pestalotiopsis sp. yielded three caprolactam analogs, pestalactams D-F, along with larger quantities of the known metabolite pestalactam A, which was methylated using diazomethane to yield 4-O-methylpestalactam A. The chem. structures of the previously undescribed fungal metabolites were determined by anal. of 1D/2D NMR and MS data. The structure of 4-O-methylpestalactam A was confirmed following single crystal X-ray diffraction anal. The antibacterial and antifungal activity of all compounds was assessed, which identified three compounds, (1S,3R)-austrocortirubin, (1S,3S)-austrocortirubin, and 1-deoxyaustrocortirubin with mild activity (100 μM) against Gram-pos. isolates and one compound, 2-hydroxy-6-methyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid, with activity against Cryptococcus neoformans and Cryptococcus gattii at 50 μM.
Phytochemistry (Elsevier) published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Product Details of C8H7ClO3.
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