Cockcroft, Xiao-ling published the artcilePhthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase, Synthetic Route of 116853-97-5, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(4), 1040-1044, database is CAplus and MEDLINE.
We have previously described the discovery of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors based on a phthalazinone scaffold. Subsequent optimization of inhibitory activity, metabolic stability and pharmacokinetic parameters has led to a novel series of meta-substituted 4-benzyl-2H-phthalazin-1-one PARP-1 inhibitors which retain low nM cellular activity and show good stability in vivo and efficacy in cell based models.
Bioorganic & Medicinal Chemistry Letters published new progress about 116853-97-5. 116853-97-5 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,acyl chloride,Ether, name is 2-Chloro-6-methoxyisonicotinoyl chloride, and the molecular formula is C7H5Cl2NO2, Synthetic Route of 116853-97-5.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics