Duan, Cancan published the artcilePharmacokinetics and tissue distribution of cantharidin after oral administration of aqueous extracts from Mylabris in rats, Formula: C12H15ClO3, the publication is Biomedical Chromatography (2021), 35(10), e5172, database is CAplus and MEDLINE.
A sensitive gas chromatog.-mass spectroscopy method was established for the determination of cantharidin (CTD) in rat plasma and liver homogenates. During the experiment, rats were randomly divided into two groups (low, high) and were administered aqueous extract of Mylabris compound for 7 days. Then, plasma and tissue samples were taken at different time points to study the pharmacokinetics and tissue distribution of CTD in rats. The selected reaction monitoring transitions for CTD and clofibrate (internal standard) were m/z 128 → 85 and m/z 169 → 141, resp. The calibration curve ranged from 10.26 to 3,078 ng/mL for plasma and from 10.26 to 246.24 ng/mL for liver homogenates. The lower limits of quantification were 10.26 ng/mL for both plasma and liver. The intra- and inter-day precision and accuracy were <20% for both plasma and liver homogenates. Extraction recovery ranged from 89.21 to 103.61% for CTD in rat plasma and liver and from 83.79 to 102.74% for IS in rat plasma and liver. Matrix effects ranged from 93.06 to 110.44% for CTD and from 91.65 to 110.80% for IS.
Biomedical Chromatography published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Formula: C12H15ClO3.
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https://en.wikipedia.org/wiki/Chloride,
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