Hamann, Lawrence G. published the artcileBenzodiazepine-based selective inhibitors of mitochondrial F1F0 ATP hydrolase, Recommanded Product: 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2004), 14(4), 1031-1034, database is CAplus and MEDLINE.
A series of benzodiazepine-based inhibitors of mitochondrial F1F0 ATP hydrolase were prepared and evaluated for their ability to selectively inhibit the enzyme in the forward direction. Compounds from this series showed excellent potency and selectivity for ATP hydrolase vs. ATP synthase, suggesting a potentially beneficial profile useful for the treatment of ischemic heart disease. The most potent member of the group of compounds thus tested was 4-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-2-(2-phenylethyl)-1H-1,4-benzodiazepine (I). I also inhibited cytochrome P 450 isoform CYP2C9. The structure of I was further modified to diminish this undesired side effect.
Bioorganic & Medicinal Chemistry Letters published new progress about 254749-11-6. 254749-11-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene, name is 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, and the molecular formula is C7H3Cl2NO2S, Recommanded Product: 2-Chloro-4-cyanobenzene-1-sulfonyl chloride.
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