Hodgson, Ernest published the artcileNutrition and metabolism of methyl donors and related compounds in the blowfly Phormia regina, Application In Synthesis of 6249-56-5, the publication is Archives of Biochemistry and Biophysics (1960), 48-54, database is CAplus and MEDLINE.
In the nutrition of P. regina (CA 51, 6894i), γ-butyrobetaine (I) or O-acetylcarnitine served as replacements for choline (II) (quant. data given), while 2-monomethylaminoethanol was a partial replacement. The relative effectiveness of the various compounds is discussed. Ethanolamine, β-hydroxybutyrate, γ-aminobutyrate, β-hydroxy-γ-aminobutyrate, trimethylamine, and sarcosine did not serve as replacements in promoting growth, even when supplemented by other metabolites (named). The II-inhibitor 2-amino-2-methylpropanol inhibited growth, but its effects could be reversed by II and compounds which could replace II. Phospholipides containing serine, ethanolamine, and II were found to be normal constituents of 3rd instar larvae. Formate was not utilized in the biosynthesis of Me groups in II synthesis, but was metabolized with liberation of CO2, both by the living larvae and their homogenates. Biosynthesis of II from ethanolamine either did not occur or was of little importance. The effectiveness of I as a replacement for II was of interest, since I has been described as a carnitine inhibitor in other organisms. Possible mechanisms of utilization are discussed. Metabolic differences in different spp. of insects are interpreted in relation to dietary requirements. 33 references.
Archives of Biochemistry and Biophysics published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application In Synthesis of 6249-56-5.
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