Licciardi, Mariano published the artcileNovel cationic polyaspartamide with covalently linked carboxypropyl-trimethyl ammonium chloride as a candidate vector for gene delivery, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is European Polymer Journal (2006), 42(4), 823-834, database is CAplus.
The non-viral gene vector properties of a protein-like polymer, the α,β-poly(N-2-hydroxyethyl)-,-aspartamide (PHEA) were investigated after its derivatization with 3-(carboxypropyl)trimethyl-ammonium chloride (CPTA) as mol. bearing cationic groups, in order to obtain stable polycations able to condense DNA. PHEA was firstly functionalized with hydrazide pendant groups by reaction with hydrazine monohydrate (HYD), obtaining the polyhydrazide α,β-poly(N-2-hydroxyethyl/carbazate)-,-aspartamide (PHEA-HYD). In this paper we reported that polymer functionalization degree can be easily modulated by varying reaction conditions, so allowing us to produce two PHEA derivatives at different molar percentage of hydrazide groups. Subsequently, condensation reaction of PHEA-HYD copolymers with CPTA yielded α,β-poly(N-2-hydroxyethyl)-N-carbazate[N’-(3-trimethylammonium chloride)propylhydrazide]-,-aspartamide (PHEA-HYD-CPTA) polycation derivatives In vitro studies were carried out to evaluate polycations ability to complex DNA and to protect it from nuclease degradation Obtained results demonstrated the good efficiency of our new PHEA-polycations derivatives, PHEA-HYD-CPTA, to complex and condense genomic material even at very low polycation/DNA weight ratio.
European Polymer Journal published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics