Maximo, Patricia published the artcilePhotomodulation of ultrastable host-guest complexes in water and their application in light-controlled steroid release, Synthetic Route of 219537-97-0, the publication is Organic Chemistry Frontiers (2022), 9(16), 4238-4249, database is CAplus.
The cucurbit[8]uril (CB8) synthetic receptor was shown to form high-affinity host-guest complexes with dicationic dithienylethene (DTE) photoswitches I [R = H, Me; R1 = 1-iodo-1-methyl-2-pyridyl, 1-iodo-1-methyl-3-pyridyl, 1-iodo-1-methyl-4-pyridyl] in water. ITC experiments combined with computational studies suggest that the formation of the inclusion complexes was mainly driven by a combination of hydrophobic effects, ion-dipole, hydrogen- and chalcogen-bonding interactions. The binding affinities were observed to be much higher for the DTE closed isomers, reaching values in the picomolar range (up to 1011 M-1) while the open isomers display up to 10 000-fold lower affinities, setting ideal conditions for the development of robust photoswitchable host-guest complexes. The light-responsive affinity of these photoswitches toward CB8 was explored to control the encapsulation and release of nanomolar affinity steroids via competitive guest replacement.
Organic Chemistry Frontiers published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Synthetic Route of 219537-97-0.
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