Qian, Bo published the artcileIron-Catalyzed Carboamination of Olefins: Synthesis of Amines and Disubstituted β-Amino Acids, SDS of cas: 1263414-46-5, the publication is Journal of the American Chemical Society (2017), 139(37), 13076-13082, database is CAplus and MEDLINE.
Intermol. carboamination of olefins with general alkyl groups is an unsolved problem. Diastereoselective carboamination of acyclic olefins represents an addnl. challenge in intermol. carboaminations. We have developed a general alkylamination of vinylarenes and the unprecedented diastereoselective anti-carboamination of unsaturated esters, generating amines and unnatural β-amino acids. This alkylamination is enabled by difunctional alkylating reagents and the iron catalyst. Alkyl diacyl peroxides, readily synthesized from aliphatic acids, serve as both alkylating reagents and internal oxidizing agents. A computational study suggests that addition of a nitrile to the carbocation is the diastereoselectivity-determining step, and hyperconjugation is proposed to account for the highly diastereoselective anti-carboamination.
Journal of the American Chemical Society published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, SDS of cas: 1263414-46-5.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
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