Tehrani, Maliheh Barazandeh published the artcilePhthalimide-1,2,3-triazole hybrid compounds as tyrosinase inhibitors; synthesis, biological evaluation and molecular docking analysis, Computed Properties of 620-20-2, the publication is Journal of Molecular Structure (2019), 86-93, database is CAplus.
A novel series of phthalimide-1,2,3-triazole hybrids linked to benzyl ring containing different substituents were synthesized and evaluated for their tyrosinase inhibitory activity (inhibitory activity and inhibition kinetic). It was found that compounds 2-((1-(2-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methyl)isoindoline-1,3-dione (I) and 2-((1-(2-bromobenzyl)-1H-1,2,3-triazol-4-yl)methyl)isoindoline-1,3-dione (II), exhibited the best tyrosinase inhibitory activity, with IC50 values of 26.20 ± 1.55 and 26.55 ± 2.31 μM, resp. The inhibition kinetic anal. of I indicated that the compound inhibited tyrosinase in a competitive manner. Moreover, mol. docking anal. was performed to study the interactions and binding modes of the tested compounds Docking results confirmed that the active inhibitors well accumulated in the mushroom tyrosinase active site.
Journal of Molecular Structure published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C10H14O2, Computed Properties of 620-20-2.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics