Xing, Siyang published the artcileDiastereoselective synthesis of cis-1,3-disubstituted isoindolines via a highly site-selective tandem cyclization reaction, Safety of Sodium chloro(tosyl)amide trihydrate, the publication is Organic Chemistry Frontiers (2018), 5(12), 1950-1956, database is CAplus.
A highly site-selective tandem reaction involving regioselective ring opening of aziridines and Michael addition of electron-deficient alkenes was described. O-atom nucleophiles, produced by the reaction of aldehydes and NHCs in open air, preferred to attack the less hindered aziridine carbons, followed by further intramol. aza-Michael addition to afford a series of cis-1,3-disubstituted isoindolines in good yields with good diastereoselectivities. High selectivities, high efficiency and mild conditions made this tandem reaction very suitable for the rapid construction of libraries of isoindoline compounds
Organic Chemistry Frontiers published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C10H17N3O2, Safety of Sodium chloro(tosyl)amide trihydrate.
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