Yuan, Tianqi published the artcileSynthesis of camphor sulfonic acid derivatives modified Mg/Al-LDH for efficient separation of propranolol enantiomers, HPLC of Formula: 21286-54-4, the publication is Applied Clay Science (2022), 106521, database is CAplus.
Designing chiral adsorption separation material with high enantioselectivity and stability is a promising route to realize the enantioselective recognition and separation of racemic mols. Here, for the first time, camphor sulfonic acid derivatives (CSA) were synthesized as a chiral resolving agent, and it was modified on Mg/Al layered double hydroxide (Mg/Al-LDH) through electrostatic self-assembly to construct functionalized chiral adsorption separation material (CSA@LDH), which could be served as an adsorbent for enantioselective recognition and separation of propranolol enantiomers (R,S-PRO). The CSA@LDH maintained the advantage of limited chiral space in layered structures to achieve the selective enrichment of R-PRO, and the e.e.% value of single separation could reach 19.5%. Meanwhile, d. functional theory (DFT) calculations supported that chiral recognition and separation were ascribed to the discrepancy in affinities stemming from the difference of π-π interaction force and hydrogen bonding capacity of CSA with R,S-PRO. Hence, considering the superior ability of hydrogen bond coordination and stereocontrol of camphor sulfonic acid derivatives, it is expected to be more widely used as a chiral resolving agent for other enantiomeric recognition and separation
Applied Clay Science published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C5H5BO5, HPLC of Formula: 21286-54-4.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics