Albrecht, William L. published the artcileBis-basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 6. Bis-basic-substituted fluoranthenes, HPLC of Formula: 4584-49-0, the publication is Journal of Medicinal Chemistry (1974), 17(11), 1150-6, database is CAplus and MEDLINE.
Bis-basic esters, ketones, ethers, and alkanes of fluoranthene, given s.c., had potent antiviral activity against encephalomyocarditis virus in mice. The ketones were the most active when given orally. For example, 3,9-fluoranthenedicarboxylic acid bis[3-(diethylamino)propyl] ester-2HCl (I) [27086-86-8] and 1,1′-(3,9-fluoranthenediyl)bis[2-(dimethylylamino)ethanone]-2HCl (II) [35689-81-7] increased the survival time of infected mice by 1.82- 1.94-fold resp., at 50 mg/kg s.c. I and II were effective against both RNA (Semliki Forest) and DNA (vaccinia) virus infections in mice. I also enhanced the antibody response to sheep erythrocytes. II was prepared by reaction of fluoranthene [206-44-0] with 2-chloroacetyl chloride [79-04-9], followed by Me2NH.
Journal of Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, HPLC of Formula: 4584-49-0.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics