Brown, Louise M. published the artcileThe destruction of cytochrome P-450 by alclofenac: possible involvement of an epoxide metabolite, HPLC of Formula: 33697-81-3, the publication is Biochemical Pharmacology (1982), 31(2), 195-9, database is CAplus and MEDLINE.
In control mouse hepatic microsomes, no evidence for metabolism of alclofenac (I) [22131-79-9] was observed, but in induced (phenobarbitone or 3-methylcholanthrene) microsomes, I was metabolized to the dihydroxy [41451-01-8] and phenolic [33697-81-3] metabolites. Destruction of cytochrome P-450 [9035-51-2] was observed when I was incubated with microsomes from phenobarbitone-treated mice, but not untreated or 3-methylcholanthrene-treated mice; the destruction was dependent on the presence of a NADPH-regenerating system and was inhibited by SKF 525A, metyrapone, glutathione, and cysteine. The metabolites caused no loss of cytochrome P-450, whereas the reactive intermediate, alclofenac epoxide [70319-10-7], was a potent inducer in the absence of NADPH. Thus, in vitro destruction of cytochrome P-450 by I is partly mediated through the formation of the reactive epoxy metabolite.
Biochemical Pharmacology published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, HPLC of Formula: 33697-81-3.
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