Cannon, Joseph G. published the artcileVinyl ethers of choline and congeners, COA of Formula: C5H13Cl2N, the publication is Journal of Medicinal Chemistry (1976), 19(7), 934-7, database is CAplus and MEDLINE.
The vinyl ethers of choline and of its α- and β-methyl homologs were prepared to determine their cholinergic effects and to determine whether a separation of the dual physiol. activity (nicotinic and muscarinic) reported for the choline vinyl ether iodide [24586-04-7] could be achieved by this modification. A literature method of vinyl transetherification of amino alcs. was studied and modified. (±)-2-(Dimethylamino)-1-propyl vinyl ether methiodide [59309-74-9] was prepared by vinyl transetherification of 2-dimethylamino-1-propanol [15521-18-3]. However, when this procedure was attempted on 1-dimethylamino-2-propanol [108-16-7], only a 4% yield of the vinyl ether was obtained. (±)-1-(Dimethylamino)-2-propyl vinyl ether methiodide [59276-15-2] was prepared by Hofmann degradation of (±)-2,4-dimethylmorpholine methiodide [59229-59-3]. Two independent, unequivocal syntheses of the (±)-1-(dimethylamino)2-propyl ethyl ether methiodide [99159-81-6] have been accomplished. The 2 literature methods for synthesis of this compound were found to be equivocal, and therefore, the biol. data previously reported for this compound may not be valid. Structure activity relationships of the ethers with respect to nicotinic and muscarinic activities are discussed.
Journal of Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, COA of Formula: C5H13Cl2N.
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