Gao, Feng-qin published the artcileSynthesis of methyl 2-chloroisonicotinate via esterification reaction catalyzed by hydrogen chloride, Name: 2-Chloroisonicotinic acid, the publication is Huaxue Shijie (2014), 55(1), 26-28, 54, database is CAplus.
Me 2-chloroisonicotinate with purity higher than 98.5% was synthesized via esterification reaction using 2-chloro-isonicotinic acid as starting material and hydrogen chloride as catalyst. The target compound was characterized by 1H NMR, IR and GC-MS. The exptl. results showed that the optimal reaction conditions were: the concentration of hydrogen chloride 26%, the reaction temperature 40°C and the reaction time 3 h. The reason for the generation of the byproduct Me 2-methoxyl isonicotinate was investigated, and the reaction mechanism was speculated.
Huaxue Shijie published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Name: 2-Chloroisonicotinic acid.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics