Biochimica et Biophysica Acta, Molecular Cell Research published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.
Gross, Carol J. published the artcileUptake of L-carnitine, D-carnitine and acetyl-L-carnitine by isolated guinea pig enterocytes, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Biochimica et Biophysica Acta, Molecular Cell Research (1986), 886(3), 425-33, database is CAplus and MEDLINE.
Uptake and metabolism of D– and L– isomers of carnitine (I), and acetyl-L–I were studied in isolated guinea pig enterocytes. Uptake of the D– and L-isomers of I was temperature dependent. Uptake of L-[14C]I by jejunal cells was Na+ dependent since replacement by Li+, K+, or choline greatly reduced uptake. L– And D–I developed intracellular-to-extracellular concentration gradients for total I (free plus acetylated) of 2.7 and 1.4, resp. However, acetylation of L–I accounted almost entirely for the difference between uptake of L– and D–I. About 60% of the intracellular label was acetyl-L–I after 30 min, and the remainder was free L–I. No other products were observed D–I was not metabolized. Acetyl-L–I was deacetylated during or immediately after uptake into intestinal cells and a portion of this newly formed intracellular free I was apparently reacetylated. L– And D–I transport (after adjustment for metabolism and diffusion) was evaluated over a concentration range of 2-1000 μM. Km Values of 6-7 μM and 5 μM were estimated for L– and D–I, resp. Ileal cell uptake was â?/2 that found for jejunal cells, but the labeled intracellular acetyl-I-to-I ratios were similar for both cell populations. I transport by guinea pig enterocytes demonstrated characteristics of a carrier-mediated process since it was inhibited by D–I and trimethylaminobutyrate, as well as being temperature and concentration dependent. The process appeared to be facilitated diffusion rather than active transport since L–I did not develop a significant concentration gradient and was unaffected by ouabain or actinomycin A.
Biochimica et Biophysica Acta, Molecular Cell Research published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.
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