Hahn, Elliot F. published the artcileNarcotic antagonists. 4. Carbon-6 derivatives of N-substituted noroxymorphones as narcotic antagonists, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (1975), 18(3), 259-62, database is CAplus and MEDLINE.
A series of 11 title compounds was prepared from naloxone [465-65-6] and naltrexone [16590-41-3] by the Wittig reaction, or by reaction with sulfur ylides or alkyllithium reagents. Most of the derivatives had oral potencies superior to the parent compounds in hot plate and tail clip tests in mice. 6-Desoxy-6-methylenenaloxone (I) [42971-34-6] and 6-desoxy-6-methylenenaltrexone (II) [55096-26-9] had the greatest increase in potency over parent compounds Structure-activity relations were discussed.
Journal of Medicinal Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Related Products of chlorides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics