Li, Huan-huan published the artcileAcute toxicity of 4-chloro-2-fluoro-3-methoxybenzeneboronic acid, Recommanded Product: (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid, the publication is Shiyong Yufang Yixue (2016), 23(2), 226-228, database is CAplus.
Objective To study the acute oral toxicity, acute dermal toxicity, acute dermal irritation and acute eye irritation of 4-chlorine-2-fluoro-3-methoxybenzeneboronic acid. Methods Tests for acute oral toxicity, acute dermal toxicity, acute dermal irritation and acute eye irritation of 4-chlorine-2-fluoro-3-methoxybenzeneboronic acid were conducted in compliance with the Guidelines for the Testing of Chems. (State Environmental Protection Administration, 2004). Results Acute oral toxicity test showed that the oral LD50 in female and male rats was 369 mg/kg (95% CI: 227-599 mg/kg) and 233 mg/kg (95% CI: 160-399 mg/kg) resp. Pulmonary congestion in the dead rats was observed by anatomy. Acute dermal toxicity test showed that the dermal LD50 in rats was higher than 2, 500 mg/kg. Acute dermal irritation test showed that the mean value of the total integral for each observation point after acute dermal exposure, and the highest integral recorded for all observation points were “0”. Acute eye irritation test showed that the eye irritation was classified into Grade 5. Conclusions Acute oral toxicity of 4-chloro-2-fluoro-3-methoxybenzeneboronic acid for female and male rats belongs to low toxicity and moderate toxicity resp. Lung may be the target organ. Acute dermal toxicity for rats is classified into practical non-toxic. It is not a dermal irritant to albino rabbits, but may be a medium ocular irritant.
Shiyong Yufang Yixue published new progress about 944129-07-1. 944129-07-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester,, name is (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid, and the molecular formula is C7H7BClFO3, Recommanded Product: (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid.
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