Park, No Sang published the artcileN-Aralkylated 4-(2-aminoethoxy)phenylacetamide derivatives as potent analgesic and antiinflammatory agents., Safety of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Korean Journal of Medicinal Chemistry (1991), 1(1), 36-43, database is CAplus.
A series of N-aralkylated 4-(2-aminoethoxy)phenylacetamide derivative 4-NH2CH2CH2O-3-R1C6H3CH2CONH(CH2)nR2 [R1 = OMe, R2 = Ph, n = 3, 4, 5; R1 = H, F, Cl, OMe, R2 = 3-MeC6H4, n = 3; R1 = H, OMe, R2 = 3-MeC6H4, n = 4; R1 = H, F, Cl, OMe, R2 = 4-MeC6H4, n = 3; etc.] were prepared for evaluation as analgesic and antiinflammatory agents. These compounds were prepared by condensation of appropriate aralkylamines with 4-hydroxyphenylacetic acid derivatives in the presence of mol. sieves followed by 2-aminoethylation on phenolic hydroxy group. Most of the new compounds exhibited very potent analgesic and antiinflammatory activities by acetic acid-induced writhing test, PBQ-induced writhing test, Randall-Selitto test and carrageenin edema test. The most interesting derivative of the series was N-[3-(3,4-dimethylphenyl)propyl]-4-(2-aminoethoxy)-3-methoxyphenylacetamide, 3,4-Me2C6H3CH2CH2CH2NHCOCH2C6H3OMe-3-(OCH2CH2NH2)-4, which showed very potent inhibition of writhing by oral administration in mice compared to those of reference compounds
Korean Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Safety of 3-Chloro-4-hydroxyphenylacetic acid.
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