Park, No Sang published the artcilePhenylacetamide derivatives as analgesic agents, Safety of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Korean Journal of Medicinal Chemistry (1991), 1(1), 2-7, database is CAplus.
A new class of compounds was synthesized by transposition of the amide bond, introduction of substituents on the aryl portion, and modification of the alkyl portion of capsaicin, 4-HO-3-MeOC6H3CH2NHCO(CH2)4CH:CHCHMe2-(E). 3-Substituted 4-hydroxy and 4-(2-aminoethoxy)phenylacetamide derivatives, 4-RO-3-R1C6H3CH2CONHR2 [R = H; R1 = H, F, Cl, OH; R2 = (E)-Me2CHCH:CH(CH2)4, octyl, nonyl, decyl; R = CH2CH2NH2; R1 = H, F, Cl, OMe; R2 = octyl, nonyl, decyl] to have high analgesic activity by the acetic acid-induced writhing test. These compounds were prepared through condensation of appropriate alkylamines with 4-hydroxyphenylacetic acids in the presence of mol. sieves in high efficiency and yields, and followed by 2-aminoethylation on phenolic hydroxy group which significantly improved activity by oral administration.
Korean Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Safety of 3-Chloro-4-hydroxyphenylacetic acid.
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