Pedroso, Enrique published the artcileSolid-phase synthesis of circular oligonucleotides, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid, the publication is Methods in Molecular Biology (Totowa, NJ, United States) (2005), 101-125, database is CAplus and MEDLINE.
A protocol for the straightforward preparation of small circular oligodeoxyribonucleotides (2-28 nt) is reported. The assembly of the oligonucleotide chain (standard phosphoramidite chem.) and cyclization by the phosphotriester method take place on a tailor-made nucleotide-derivatized solid support. Although cyclization yields are moderate, the procedure exploits a synthesis design that allows selective cleavage of the circular oligonucleotide from the support, which facilitates isolation of the target mol. by simple filtration.
Methods in Molecular Biology (Totowa, NJ, United States) published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid.
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