Reheim, Mohamed Ahmed Mahmoud Abdel published the artcileA simple and convenient synthesis of isolated fused heterocycles based on: 6-phenyl-2-thioxo-2,3- dihydropyrimidin-4(5H)-one and 5-acetyl-6-phenyl-2- thioxo-2,3-dihydropyrimidin-4(5H)-one, Category: chlorides-buliding-blocks, the publication is Heterocycles (2016), 92(8), 1397-1414, database is CAplus.
The reaction of 6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one with acetyl chloride in acetic anhydride in the presence of sodium acetate afforded 5-acetyl-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one which was reacted with bromine, hydrazine hydrate, phenylhydrazine, cyanothioacetamide, aldehydes ArCHO (Ar = Ph, 4-chlorophenyl, 4-methoxyphenyl) and (malononitrile/sulfur) to give 2-thioxo-2,3-dihydropyrimidine derivatives, e.g., I. In the present investigation 6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one was reacted with chloroacetyl chloride to yield the corresponding compound 5-(2-chloroacetyl)-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one. Compound 6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one was reacted with some electrophilic reagents such as benzylidene-cyanothioacetamide derivatives, 2-cyano-2-cyclopentylethanethioamide, 2-cyano-2-cyclohexyl-ethanethioamide and aromatic diazonium salts Ar1N2+Cl– to give compounds, e.g., II (X = CH2, CH2CH2). The newly synthesized heterocycles were characterized on the basis of their chem. properties and spectral data.
Heterocycles published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Category: chlorides-buliding-blocks.
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Chlorides – an overview | ScienceDirect Topics