Tan, Derek S. published the artcileSynthesis and Preliminary Evaluation of a Library of Polycyclic Small Molecules for Use in Chemical Genetic Assays, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Journal of the American Chemical Society (1999), 121(39), 9073-9087, database is CAplus.
(-)-Shikimic acid, was converted into both enantiomers of 2-hydroxyoxabicyclo[4.1.0]hept-3-ene-4-carboxylic acid which were attached to a solid support via a photocleavable linker. Tandem acylation-1,3-dipolar cycloaddition with nitrones yielded tetracyclic templates I. After development of several efficient coupling reactions of I and completion of extensive validation protocols, a split-pool synthesis yielded a binary encoded library calculated to contain 2.18 million polycyclic compounds These compounds are compatible with miniaturized cell-based forward chem. genetic assays designed to explore biol. pathways and reverse chem. genetic assays designed to explore protein function. As a simple illustration of the potential of these compounds, several were shown to activate a TGF-β-responsive reporter gene in mammalian cells.
Journal of the American Chemical Society published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C12H15NO, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.
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