Wang, Gren Z. published the artcileCCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood, Synthetic Route of 32333-53-2, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(24), 7291-7294, database is CAplus and MEDLINE.
A series of N,S-diarylsulfonamides was identified as hCCR2 receptor antagonists but suffered from high plasma protein binding resulting in a >100 fold shift in activity in a functional GTPγS assay run in tandem in the presence and absence of human serum albumin. Introduction of an aryl amide with ethylenediamine linker led to compounds with reduced shifts and improved activity in whole blood.
Bioorganic & Medicinal Chemistry Letters published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C9H20Cl2Si, Synthetic Route of 32333-53-2.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics