Xiao, Peng-Fei published the artcileDiscovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold, Safety of 2-Chloro-4-methylphenylboronic acid, the publication is Chinese Chemical Letters (2014), 25(5), 673-676, database is CAplus.
Dipeptidyl peptidase IV (DPP4) inhibitors were proven in the treatment of type 2 diabetes. A series of novel indole compounds was synthesized that selectively inhibit the activity of DPP4 over dipeptidyl peptidase 9 DPP9 (>200 fold). It was further co-crystallized DPP4 with indole sulfonamide to confirm a proposed binding mode. Good metabolic stability of the indole compounds represented another pos. attribute for further development.
Chinese Chemical Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C9H10N2O, Safety of 2-Chloro-4-methylphenylboronic acid.
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