Zhang, Jian published the artcilePurine Nucleoside Derivatives Containing a Sulfa Ethylamine Moiety: Design, Synthesis, Antiviral Activity, and Mechanism, Quality Control of 32333-53-2, the publication is Journal of Agricultural and Food Chemistry (2021), 69(20), 5575-5582, database is CAplus and MEDLINE.
To find efficient and broad-spectrum viral agents, a series of purine nucleoside derivatives containing sulfa ethylamine moieties was designed and synthesized, and their antiviral activities against tobacco mosaic virus (TMV), cucumber mosaic virus (CMV), and potato virus Y (PVY) were evaluated. Some target compounds displayed good antiviral activities. Among them, compound I showed excellent protective activity against CMV and PVY with 50% effective concentration values (EC50) of 137 and 209μg/mL, resp., which were better than that of the control agent ningnanmycin (508 and 431μg/mL). Moreover, the EC50 value of compound I for the inactivating activity against TMV was 48μg/mL, which was better than that of ningnanmycin (88μg/mL). In addition, compound I not only destroyed the structure of the TMV virus but also had a good interaction with the coat protein of the TMV virus. Therefore, compound I may further destroy the structure of the virus by binding to the coat protein of the TMV virus, thereby weakening the infectivity of the virus.
Journal of Agricultural and Food Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C11H24O3, Quality Control of 32333-53-2.
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