Zhu, Junsheng published the artcileDesign, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase, Name: 3-Chloro-4-fluoronitrobenzene, the publication is Journal of Medicinal Chemistry (2015), 58(3), 1123-1139, database is CAplus and MEDLINE.
N-arylthiazoleamines such as (arylamino)thiazolecarboxylates I (R = Ph, 4-MeOC6H4, 4-ClC6H4, 4-F3CC6H4, 4-F3CC6H4, 4-t-BuC6H4, 4-Cl-3-F3CC6H3, 4-Br-3-F3CC6H3, 3,4-Cl2C6H3, 3,5-Cl2C6H3, 4-Br-2-MeC6H3, 5-indanyl, 1,3-benzodioxol-5-yl, 5,6,7,8-tetrahydro-2-naphthyl, 2-naphthyl, 2-anthracenyl, 4-PhC6H4, 2-R1-6-R2-4-R3C6H2, 3-Cl-4-R4OC6H3; R1, R2 = H, F; R3 = Ph, 3-MeOC6H4; R4 = Ph, PhCH2, 2-Cl-6-FC6H3CH2) were prepared as inhibitors of human dihydroorotate dehydrogenase (HsDHODH), a potential therapeutic target for the treatment of rheumatoid arthritis and other autoimmune diseases; their calculated and exptl. binding to HsDHODH and binding to the corresponding enzyme from Plasmodium falciparum were determined The structures of complexes of two arylaminotriazoles bound to HsDHODH were determined by X-ray crystallog.; the structures confirmed that the inhibitors bound at the putative ubiquinone binding tunnel and guided the development of improved analogs, such as I (R = 5-indanyl). I (R = 5-indanyl) inhibited inflammation and alleviated foot swelling in rats.
Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C5H10Cl3O3P, Name: 3-Chloro-4-fluoronitrobenzene.
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