Coumarin as a Surrogate for the Protection-group-free Synthesis of o-Hydroxy Stilbenes: Hydrolysis-Decarboxylation-Heck Coupling Reactions in One Pot was written by Andhare, Nitin H.;Equbal, Danish;Sinha, Arun K.. And the article was included in Chemistry – An Asian Journal in 2022.Safety of Lithium chloride The following contents are mentioned in the article:
Here, a successful attempt is made to develop a one-pot protocol for the synthesis of 2-hydroxystilbene derivatives I (R = Ph, naphthalen-2-yl, thiophen-2-yl, benzo[d][1,3]dioxol-5-yl, etc.; R1 = H, Me) via hydrolysis of natural coumarins II followed by in situ decarboxylative Heck coupling with haloarenes RX (X = I, Br). Fine tuning of the reaction conditions allowed exclusive formation of 2-hydroxystyrylbenzenes I over other possible side products, i.e., benzofuran/substituted coumarins. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Safety of Lithium chloride).
Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of Lithium chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics