Synthesis of 1-sulfonyl-2-arylpyrrolidines via intramolecular cyclization/Mannich-type reaction cascade of N-(4,4-diethoxybutyl)sulfonamides was written by Anikina, Ekaterina A.;Smolobochkin, Andrey V.;Gazizov, Almir S.;Burilov, Alexander R.;Pudovik, Michail A.. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2018.Safety of 4-Chlororesorcinol The following contents are mentioned in the article:
Herein, we report the successful application of a novel approach to 2-substituted pyrrolidines based on intramol. cyclization/intermol. Mannich-type cascade reaction of N-(4,4-diethoxybutyl)sulfonamides to the synthesis of pyrrolidines possessing heterocyclic and polyaromatic moieties. The proposed approach benefits from mild reaction conditions, moderate to high yields of target compounds and provides a convenient route to the previously unknown 1-sulfonyl-2-arylpyrrolidines. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Safety of 4-Chlororesorcinol).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of 4-Chlororesorcinol
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics