3-Benzo[b]furyl- and 3-benzo[b]thienylaminobutyric acids as GABAB ligands. Synthesis and structure-activity relationship studies was written by Ansar, M.;Ebrik, S. Al Akoum;Mouhoub, R.;Berthelot, P.;Vaccher, C.;Vaccher, M. P.;Flouquet, N.;Caignard, D. H.;Renard, P.. And the article was included in European Journal of Medicinal Chemistry in 1996.Application In Synthesis of 3-Chloro-2-hydroxy-5-methylbenzaldehyde The following contents are mentioned in the article:
Baclofen (β-p-chlorophenyl GABA) is one of the selective agonists for the bicuculline-insensitive GABAB receptors. In the search for new compounds that bind to GABAB receptors it is very important to clarify the structural requirements. The syntheses of the binding studies on various 3-heteroaromatic (benzo[b]furyl- and benzo[b]thienyl)aminobutyric acids is reported. 4-Amino-3-(7-methyl-benzo[b]furan-2-yl)butanoic acid (I) is a potent and specific ligand for GABAB receptors, with an IC50 value of 5.4 μM in the displacement of [3H]GABA. This study involved multiple reactions and reactants, such as 3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4Application In Synthesis of 3-Chloro-2-hydroxy-5-methylbenzaldehyde).
3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 3-Chloro-2-hydroxy-5-methylbenzaldehyde
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics