Potential antitumor agents. 14. Acridylmethanesulfonanilides was written by Cain, Bruce F.;Seelye, Ralph N.;Atwell, Graham J.. And the article was included in Journal of Medicinal Chemistry in 1974.Safety of 2-Chloro-4-sulfamoylbenzoic acid The following contents are mentioned in the article:
A series of 74 structural variants of 4′-(9-acridinylamino)methanesulfonanilide hydrochloride (I) [35440-46-1] was prepared by coupling of the appropriate chloroheterocycle with a p-aminosulfonanilide. In tests in mice, 13 compounds provided some indefinite survivors of i.p. inoculation of L 1210 leukemia. Activity in relation to structure and lipophilicity was discussed. This study involved multiple reactions and reactants, such as 2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3Safety of 2-Chloro-4-sulfamoylbenzoic acid).
2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 2-Chloro-4-sulfamoylbenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics