Practical regioselective halogenation of vinylogous esters: synthesis of differentiated mono-haloresorcinols and polyhalogenated resorcinols was written by Chen, Xiaohong;Liu, Xiaoguang;Martinez, Jenny S.;Mohr, Justin T.. And the article was included in Tetrahedron in 2016.Safety of 4-Chlororesorcinol The following contents are mentioned in the article:
A practical and efficient method for the direct, regioselective conversion of vinylogous esters to haloresorcinols is reported. Control of the reaction conditions enables synthesis of either the 4- or 6-haloresorcinol isomers from a common precursor with excellent regiocontrol and high yield. The generality and functional group tolerance of this novel protocol is demonstrated. The utility of this methodol. to access polyhaloresorcinols is also reported. These methods create useful functionalized building blocks for further synthetic applications. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Safety of 4-Chlororesorcinol).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 4-Chlororesorcinol
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics