Organic Base-Mediated Carboxylation of (Hetero)aromatic Compounds Using Supercritical Carbon Dioxide (scCO2) was written by Chetty, Lloyd C.;Kruger, Hendrik G.;Arvidsson, Per I.;Naicker, Tricia;Govender, Thavendran. And the article was included in Synthesis in 2022.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:
A straightforward site-selective method for the direct carboxylation of resorcinols (3-hydroxyphenol derivatives), phenols ROH (R = Ph, 3-hydroxyphenyl, 2-methyl-3-hydroxyphenyl, etc.), and indoles I (R1 = H, Br, nitro) is reported. The products were obtained in moderate to high yields using supercritical carbon dioxide as an electrophile and solvent under basic conditions. This method offers solvent and metal free conditions without the cumbersome exclusion of air or water with convenient purification This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C6H5ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics