4,4-Disubstituted cyclohexylamine based CCR5 chemokine receptor antagonists as anti-HIV-1 agents was written by Duan, Maosheng;Aquino, Christopher;Dorsey, George F.;Ferris, Robert;Kazmierski, Wieslaw M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Recommanded Product: 53250-84-3 The following contents are mentioned in the article:
A series of 4,4-disubstituted cyclohexylamine based CCR5 antagonists has been designed and synthesized. The prepared derivatives contain arylsulfonamides and differentially linked (benzimidazolyl)azabicyclooctane moieties. Their antiviral structure-activity relationship has been extensively explored, and compound I was found to be most potent of the antagonists studied. This study involved multiple reactions and reactants, such as 2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3Recommanded Product: 53250-84-3).
2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 53250-84-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics