Design, Synthesis and Cytotoxic Activities of Pyrazole-Perimidine Hybrids was written by Guemues, Mehmet;Guemues, Nisa;Eroglu, Halil Erhan;Koca, Irfan. And the article was included in ChemistrySelect in 2020.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
Nine perimidine-pyrazole hybrids I [R = H, Me, Cl; Ar = Ph, 4-MeC6H4, 2-MeOC6H4, 4-FC6H4, 4-BrC6H4] were designed and synthesized. Genotoxic, mutagenic and carcinogenic effects of two of the synthesized compounds I [R = H, Ar = 4-MeC6H4; R = Me, Ar = 4-BrC6H4] were evaluated. The tested compounds could cause chromosomal damage by genotoxic potential and mitotic delay by cytotoxic potential at high concentrations (25-100μM). This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics