Tandem α-Arylation/Cyclization of 4-Haloacetoacetates with Arynes: A Metal-Free Approach toward 4-Aryl-3-(2H)-furanones was written by John, Jubi;Omanakuttan, Vishnu K.;T., Aneeja;Suresh, Cherumuttathu H.;Jones, Peter G.;Hopf, Henning. And the article was included in Journal of Organic Chemistry in 2019.Product Details of 638-07-3 The following contents are mentioned in the article:
An efficacious, metal-free strategy has been developed for the synthesis of 4-aryl-3-(2H)-furanones. The reaction proceeds via the nucleophilic addition of an active methylene compound to the aryne followed by ring closing of the adduct. The reaction proceeds under mild conditions, is applicable for gram-scale synthesis of 4-aryl-3-(2H)-furanones, and is general for a range of substituted arynes and haloacetates. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Product Details of 638-07-3).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 638-07-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics