Synthesis and properties of novel 4-(diarylmethyl)pyridines based on pyridoxal 5′-phosphate was written by Kibardina, L. K.;Trifonov, A. V.;Pudovik, M. A.;Gazizov, A. S.;Burilov, A. R.. And the article was included in Russian Chemical Bulletin in 2022.Synthetic Route of C6H5ClO2 The following contents are mentioned in the article:
The reaction pyridoxal 5′-phosphate with resorcinols in EtOH in the presence of concentrated HCl formed hydrochlorides of the corresponding 4-(diarylmethyl)pyridines. Refluxing ethanol solutions of the latter leaded to intramol. dehydration giving 5H-chromeno [2,3-c]-pyridines of betaine nature. This cyclization proceeded with the participation of phenolic hydroxy groups of pyridoxal 5′-phosphate and one hydroxy group of the resorcinol moieties of these substrates. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Synthetic Route of C6H5ClO2).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C6H5ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics