Synthesis, characterization and anti-microbial activity of novel pyrimidine derivatives was written by Kumar, Konda Ravi;Sumanjali, K. N. S. Sneha;Chandana, M. Priya;Srilatha, N.;Rao, P. Koteswara. And the article was included in Journal of Drug Delivery and Therapeutics in 2021.Quality Control of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
Chalcones reacted with aminoguanidine to give intermediate compounds which on further reacted with substituted ketones to give pyrimidine derivatives A total of 6 compounds were synthesized from one scheme and they were recrystallized by appropriate solvents. They were identified and characterized by various spectral methods. In the present study, all synthesized compounds tested for antibacterial activity and anti-fungal activity. They showed significant activity when compared with standard drug Streptomycin and Miconazole resp. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Quality Control of Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Quality Control of Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics