Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors was written by Li, Gudong;Zhang, Wei;Xie, Yuting;Li, Yang;Cao, Rao;Zheng, Guojun;Huang, Niu;Zhou, Yu. And the article was included in Journal of Chemical Information and Modeling in 2020.Product Details of 6294-17-3 The following contents are mentioned in the article:
Pim-1 kinase has been widely regarded as an attractive target for anticancer drugs. Here, we reported our continued efforts in structure-based optimization of compound 10-DEBC, a previously identified micromolar Pim-1 inhibitor. Guided by the Site Identification by Ligand Competitive Saturation (SILCS) method, we quickly obtained a series of 10-DEBC derivatives with significantly improved activity and selectivity. In particular, compound 26 exhibited an IC50 value of 0.9 nM, as well as 220- and 8-fold selectivity over Pim-2 and Pim-3 kinases, resp. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Product Details of 6294-17-3).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 6294-17-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics