Iodine-catalyzed synthesis of 5-benzoyl-8H-phthalazino[1,2-b]quinazolin-8-one derivatives via a domino reaction involving a benzyl automatic oxidation by oxygen was written by Liu, Jian-Quan;Feng, Bin-Bin;Wang, Xiang-Shan. And the article was included in Tetrahedron in 2018.Quality Control of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:
A one-pot procedure for the synthesis of 5-benzoyl-8H-phthalazino[1,2-b]quinazolin-8-ones was achieved by an iodine-catalyzed reaction of 2-aminobenzohydrazides and 2-alkynylbenzaldehydes in good yields. The salient feature of this strategy is a domino type process including a condensation, addition, hydroamination, and a noteworthy benzyl automatic oxidation by oxygen under metal-catalyst-free conditions. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Quality Control of 5-Chloro-2-(phenylethynyl)benzaldehyde).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 5-Chloro-2-(phenylethynyl)benzaldehyde
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics