Green Synthesis of 3-Substituted-4-arylmethylideneisoxazol-5(4H)-one Derivatives Catalyzed by Salicylic Acid was written by Mosallanezhad, Asiyeh;Kiyani, Hamzeh. And the article was included in Current Organocatalysis in 2019.Quality Control of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
The efficient and environmental friendliness procedure for the synthesis of isoxazol-5(4H)-ones was introduced. Salicylic acid was used as an inexpensive, easy to handle and safe catalyst for the synthesis of title compounds 3-Substituted-4-arylmethylideneisoxazol-5(4H)-ones were obtained from readily available aryl/heteroaryl aldehydes and β-keto esters via the cyclocondensation reaction without using thermal, microwave or ultrasound conditions. It must be highlighted that the procedure is operationally mild and simple, and the desired small heterocycles were obtained in good to high yields. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Quality Control of Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics