CuI/I2-promoted electrophilic tandem cyclization of 2-ethynylbenzaldehydes with ortho-benzenediamines: Synthesis of Iodoisoquinoline-Fused Benzimidazoles was written by Ouyang, Huang-Che;Tang, Ri-Yuan;Zhong, Ping;Zhang, Xing-Guo;Li, Jin-Heng. And the article was included in Journal of Organic Chemistry in 2011.Formula: C15H9ClO The following contents are mentioned in the article:
An efficient tandem route to the synthesis of iodo isoquinoline-fused benzimidazole derivatives, e.g., I including an iodocyclization strategy has been developed. In the presence of CuI, a variety of 2-ethynylbenzaldehydes underwent the tandem reaction with benzenediamines and iodine to afford the corresponding iodo isoquinoline-fused benzimidazoles in moderate to good yields. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Formula: C15H9ClO).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C15H9ClO
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics