Construction of benzothiophene fused pyrrolidone in water via a catalyst-free process and a mechanism study was written by Shen, Jinhui;Yu, Aimin;Zhang, Lei;Meng, Xiangtai. And the article was included in Green Chemistry in 2020.Synthetic Route of C6H9ClO3 The following contents are mentioned in the article:
A novel three-component domino reaction toward benzothiophene fused pyrrolidone derivatives I [R1 = H, 5-Br, 5-OMe, etc.; R2 = n-Bu, cyclopentyl, Bn, etc.] was developed in an environmentally benign manner. The reaction proceeded well in aqueous media, and delivered the desired products I in high yields with excellent selectivity. D. functional calculations located a multi-step reaction pathway and identified the intramol. nucleophilic addition step to be the rate-determining step. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Synthetic Route of C6H9ClO3).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C6H9ClO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics