Synthesis of 1-(arylsulfonyl)pyrrolidines from aryl alcohols and 1-[(4-chlorophenyl)sulfonyl]-2-ethoxypyrrolidine was written by Smolobochkin, A. V.;Anikina, E. A.;Gazizov, A. S.;Burilov, A. R.;Pudovik, M. A.. And the article was included in Russian Journal of Organic Chemistry in 2017.Electric Literature of C6H5ClO2 The following contents are mentioned in the article:
Acid-catalyzed reaction of 1-[(4-chlorophenyl)sulfonyl]-2-ethoxypyrrolidine with aryl alcs. led to the formation of new 1-(arylsulfonyl)pyrrolidines. The reaction proceeded under mild conditions and might be used as a convenient method for the synthesis of pyrrolidine-1-sulfonylarene derivatives containing a phenol fragment in the position 2. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Electric Literature of C6H5ClO2).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C6H5ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics