Development of a Scalable Lanthanide Halide/Quaternary Ammonium Salt System for the Nucleophilic Addition of Grignard Reagents to Carbonyl Groups and Application to the Synthesis of a Remdesivir Intermediate was written by Stevens, Andrew C.;Brak, Katrien;Bremner, W. Stacy;Brown, Angela M.;Chtchemelinine, Andrei;Heumann, Lars;Kerschen, James A.;Subotkowski, Witold;Vieira, Tiago;Wolfe, Lydia C.;Xu, Boran;Yu, Chia-Yun. And the article was included in Organic Process Research & Development in 2022.Recommanded Product: Tetramethylammonium chloride The following contents are mentioned in the article:
This manuscript describes the development and implementation of a scalable additive system, consisting of a lanthanide salt and a solubilizing quaternary ammonium salt, to improve the yield and robustness of the addition of an organomagnesium reagent to a ribonolactone en route to remdesivir. This system was found to be generally applicable in enhancing other challenging organomagnesium additions to enolizable and hindered carbonyl-containing compounds This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Recommanded Product: Tetramethylammonium chloride).
Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: Tetramethylammonium chloride
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